Notably, lncRNA-NEF expression exhibited a significant correlation with Ankylosing spondylitis disease activity score (ASDAS), Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP) levels (p < 0.05). This evidence concerns the gene CRP and ankylosing spondylitis.