It is now admitted that bulk glioblastoma tumors harbor cancer stem cells, a distinct subpopulation of cancer cells which are able to initiate new tumor after serial transplantation, have a long-term self-renewal capacity, and are resistant to radio-chemotherapy driving relapses.66 Various authors, including us, observed a high GD3 expression in stem-like cells sampled from glioblastoma bulk.39,67 Moreover, these cells also expressed a high amount of GD3S. The gene discussed is ST8SIA1; the disease is glioblastoma.