First, the evaluation of a vaccine with conjugation of GD3-lactone with KLH was associated with immunogenic response in 12 patients with melanoma, and all patients with a saponin immunologic adjuvant, QS-21 (n = 6), developed antibodies against GD3.69 Another approach corresponded to the use of Bec2, that appeared to mimic GD3 and could induce anti-GD3 antibody response in patients. This evidence concerns the gene KCNH4 and melanoma.