Beyond its response to heat stress, HSP90B1 plays a significant part in adapting to diverse tumor microenvironmental factors such as glucose deficiency (Pugh et al., 2022), hypoxia (Byun et al., 2023), acidosis (Boussadia et al., 2018), and immune stimulation (Lin et al., 2020). Here, HSP90B1 is linked to neoplasm.