The pathophysiologically-relevant PI3K/AKT/mTOR pathway, a classic pathway for tumor regulation, is also a critical target in tumor therapy due to its role in modulating autophagic activity (Itakura & Mizushima, 2010; Popova & Jücker, 2021; Xu et al., 2020). The gene discussed is MTOR; the disease is neoplasm.