It acts as a chaperone for toll-like receptor (TLR) (Graustein et al., 2018), integrin subunit (Liu & Li, 2008), and wnt co-receptor low-density lipoprotein receptor-associated protein (LRP6) (Liu et al., 2013), which are implicated in tumor microenvironment and tumor cell stemness (Santos et al., 2023; Tang et al., 2021). This evidence concerns the gene LRP6 and neoplasm.