Loss of phospholipid-remodeling enzyme lysophosphatidylcholine acyltransferase 3 (LPCAT3) or driving endogenous cholesterol synthesis through activation of sterol regulatory element-binding protein 2 (SREBP-2) in ApcMin/+ mice markedly promotes intestinal tumor formation, suggesting the crucial importance of cholesterol synthesis and availability in regulation of APC-driven intestinal tumorigenesis (72). This evidence concerns the gene SREBF2 and intestinal neoplasm.