In addition, the Ang-2/Tie signalling and VEGF signalling pathways synergistically promote tumour neo-angiogenesis, blockade of Ang-2 and VEGF delays tumour growth and enhances survival benefits through reprogramming of tumour-associated macrophages toward an antitumour phenotype as well as by pruning immature tumour vessels (25). This evidence concerns the gene TIE1 and neoplasm.