After reclustering, a total of ten major cell clusters were obtained as follows: three stromal cell types [endothelial cells (PECAM1), epithelial cells (EPCAM and KRT18), and cancer-associated fibroblasts (CAFs; COL1A1)]; seven immune cell types [CD4+ T cells (CD4), CD8+ T cells (CD8A), B cells (CD79A and MS4A1), plasma cells (JCHAIN), macrophages (CD68), monocytes (CD14 and FCGR3A), and mast cells (TPSB2)] (Figure 6A; Supplementary Figure S4). The gene discussed is JCHAIN; the disease is cancer.