The PI3K/AKT signaling pathway is involved in multiple biological processes such as Th2 cell differentiation, antigen recognition and presentation by toll-like receptor 2 (TLR2), NF-κB activation by reactive oxygen species (ROS), and mTOR phosphorylation, consequently, it exerts an impact on asthma inflammation and airway epithelial repair process (Athari, 2019). This evidence concerns the gene AKT1 and asthma.