Kaempferol can inhibit airway inflammation and airway remodeling by interfering with signal transduction in mast cells and recombinant nicotinamide adenine dinucleotide phosphate oxidase 4 (NOX4)-mediated autophagy, effectively improving allergic asthma symptoms in guinea pigs (Shin et al., 2015; Molitorisova et al., 2021; Xu et al., 2023). This evidence concerns the gene NOX4 and allergic asthma.