The PI3K/AKT signaling pathway is involved in multiple biological processes such as Th2 cell differentiation, antigen recognition and presentation by toll-like receptor 2 (TLR2), NF-κB activation by reactive oxygen species (ROS), and mTOR phosphorylation, consequently, it exerts an impact on asthma inflammation and airway epithelial repair process (Athari, 2019). The gene discussed is TLR2; the disease is asthma.