The relatively low frequency NR_SVA_381 (19.8%) that is significantly more prevalent in PD than healthy controls (Table 6) is strongly associated with the HLA-DPA1*02 and –DPA1*04 allele lineages, and with at least 9 HLA-DPB1 allele lineages (Table 7). This evidence concerns the gene HLA-DPB1 and Parkinson disease.