(35) in an analysis of 2843 European PD cases from two separate cohorts including healthy controls found that the HLA class II risk alleles were HLA-DRB1*15:01, -DQA1*01:02 and -DQB1*06:02, and the protective alleles were -DRB1*04:04, -DQA1*03:01, and -DQA1*03:02. This evidence concerns the gene HLA-DRB1 and Parkinson disease.