The effects of R_SVA_85 and NR_SVA_381 on the gene expression of HLA-DPA1 and -DPB1 genes (Figure 4), either separately or together, is of interest also for unrelated hematopoietic cell transplantation because the level of expression of HLA-DP in the recipient is an important prognostic indicator of donor-anti-host recognition and for evaluating the risk of graft-versus-host disease (67, 68). This evidence concerns the gene HLA-DPA1 and graft versus host disease.