HLA-DRB1 and autoimmune disease: Therefore, R_SVA_27 is an unique autoimmune disease marker because its linkage to the DRB1*15:01/DQA1*01:02/DQB1*06:02 haplotype has been associated with multiple sclerosis (38, 70–72), and the R_SVA_27/DRB1*16/DQB*05 haplotype was associated with other autoimmune diseases (73, 74).