Accordingly, infection or cellular stressors can lead to cell death by the combinatory crosstalk of pyroptotic, apoptotic, and necroptotic molecules (like ZBP1, RIPK1, RIPK3, CASP1, CASP8, and NLRP3, MLKL, and GSMDs) to effectively control pathogenic invasion (Christgen et al., 2020). The gene discussed is CASP1; the disease is infection.