<h4>Background</h4>Several recent studies have proposed the possible application of positron emission tomography/computed tomography (PET/CT) administering radiolabelled fibroblast-activation protein (FAP) inhibitors for various forms of thyroid cancer (TC), including differentiated TC (DTC), and medullary TC (MTC).<h4>Methods</h4>The authors conducted an extensive literature search of original studies examining the effectiveness of FAP-guided PET/CT in patients with TC. This evidence concerns the gene FAP and thyroid cancer.