ACSL4 and metabolic dysfunction-associated steatotic liver disease: The ability of Zexie decoction ability to treat NAFLD by controlling ferroptosis was confirmed when it was discovered that Zexie decoction could increase the levels of FSP1, dose-dependently upregulate Nrf2 nuclear protein expression and significantly reduce ACSL4 mRNA expression (92).There are many TCM compound formulas for the treatment of NAFLD.