LPCAT3 and cancer: Inhibiting LPCAT3 can make cancer cells less sensitive to ferroptosis, and experimenters exposed kidney cancer cell lines treated with LPCAT3 inhibitors to certain concentrations of ferroptosis inducers and found that the treated cells were insensitive to ferroptosis, while the levels of arachidonic acid phospholipids decreased significantly, indicating that inhibiting LPCAT3 decreased the synthesis of specific lipids that trigger ferroptosis, and the cells were much less likely to undergo ferroptosis, confirming the important role of LPCAT3 in ferroptosis (28).