Furthermore, a study has revealed that the interplay between specific genetic factors, such as the coexistence of the GG genotype of IL-17A rs2275913 and a mutation in the filaggrin gene (2282del4), can significantly heighten the risk of AD, highlighting the complexity of IL-17A’s role in AD and underscoring the need for further research to fully elucidate its mechanisms of action and potential as a therapeutic target (148). Here, FLG is linked to Alzheimer disease.