Evaluation of both LAMB1 and Histone H4 proteins in PCa and normal prostate tissues using commercial TMA found that both markers (P = 0.0094 and 0.0045, respectively) have increased expression in PCa tissue compared to normal tissue (Figure6A,B), indicating that relative expression of sEV proteins LAMB1 and Histone H4 in PCa plasma and urine is aligned with PCa tissue and that possibly sEV LAMB1 in blood and Histone H4 in urine are secreted by PCa cells. The gene discussed is LAMB1; the disease is posterior cortical atrophy.