ELISA results showed a significant difference in sEV protein LAMB1 expression between PCa and control groups, further demonstrating an improved diagnostic value of sEV LAMB1 in PCa with a higher individual AUC value at 0.9182 (95% CI from 0.8167 to 1; P < 0.0001) than serum PSA value at 0.8242 (95% CI from 0.7154 to 0.9331; P = 0.0002), or combined LAMB1 and PSA AUC value of 0.9348 (95% CI from 0.8495 to 1; P < 0.0001), (Figure 5B). The gene discussed is LAMB1; the disease is posterior cortical atrophy.