The increased accuracy for mPCa diagnosis using plasma sEV LAMB1 is shown in Figure 5B with area under curve (AUC) values of 0.9524 [95% confidence interval (CI) from 0.8769 to 1; P<0.0001] and 0.8643 (95% CI from 0.7282 to 1; P = 0.0001) compared to control and localised primary PCa, respectively. Here, LAMB1 is linked to posterior cortical atrophy.