For example, hesperidin alleviated oxidative stress, inflammation, and apoptosis in rat neurotoxicity or mice myocardial ischemia by regulating the B-cell lymphoma 2 (Bcl-2)/Bcl-2-associated X protein (Bax)-cysteine-aspartic acid protease 3 (caspase-3) [14] or the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway [15]. This evidence concerns the gene NFE2L2 and myocardial ischemia.