Although we did not observe the difference of CD8 intensity between HSPA4 upregulation group and normal expression group (Fig. 6C), the spatial distribution results indicated that HSPA4 was negatively correlated with the average distribution density of CD8+ T cells and the average distance from CD8+ T cells to HSPA4+ALKBH5+ tumor cells (Fig. 6E). Here, HSPA4 is linked to neoplasm.