Meanwhile, transgenic expression of miR-574-5p was found to induce serum secretion of anti-nuclear antibody, to increase the renal deposit of complement C3 and IgG and the spleen expression of a few inflammation-related genes, whereas in vivo silencing of miR-574-5p greatly alleviated SLE and lupus nephritis in the lupus-prone B6.MRL-Faslpr/J mice. Here, C3 is linked to lupus nephritis.