Dysregulation in TLR7/8 signaling is believed to be closely associated with viral and microbial infections as well as the development of neurodegeneration, cancers and autoimmune diseases including systemic lupus erythematosus (SLE) and rheumatoid arthritis, asthma, psoriasis and Type I diabetes mellitus [8, 11, 16–18]. Here, TLR7 is linked to autoimmune disease.