Finally, we demonstrate the ability of miR-574-5p to induce lupus-like features in mice, including systemic inflammation, increased production of autoantigen Sp100 and autoantibodies ANA and anti-dsDNA, the renal deposit of complement C3 and IgG, whereas its down-regulation significantly alleviates most symptoms associated with lupus and lupus nephritis. This evidence concerns the gene SP100 and lupus nephritis.