Finally, we demonstrate the ability of miR-574-5p to induce lupus-like features in mice, including systemic inflammation, increased production of autoantigen Sp100 and autoantibodies ANA and anti-dsDNA, the renal deposit of complement C3 and IgG, whereas its down-regulation significantly alleviates most symptoms associated with lupus and lupus nephritis. The gene discussed is SP100; the disease is systemic lupus erythematosus.