Through the use of the Chinese Glioma Genome Atlas (CGGA), and cancer genome atlas (TCGA) we demonstrated the high expression in multiple histologic diagnoses of grade IV gliomas (oligodendroglioma, IDH mutant astrocytoma and glioblastoma-GBM) in these two databases, CCGA – left, TCGA- right (Fig. 1a) [30]. Here, IDH2 is linked to glioma.