CPLX1 and Alzheimer disease: Higher protein levels of complexin I and II, synaptosome-associated protein of 25 kDa (SNAP25), syntaxin-1A and 1B (STX1A/B) and vesicle-associated membrane proteins 1/2 (VAMP1/2), have previously been associated with cognition, after correcting for the amount of AD pathology in post-mortem tissue, in different cortical regions susceptible to AD, including the hippocampus [185].