SYN1 and Alzheimer disease: In contrast, in a different cohort using Western blot, only the postsynaptic protein PSD-95 was preserved in resilient individuals, while all other pre- and postsynaptic proteins, such as Debrin, synapsin-1 (SYN1) or synapse associated protein 97 (SAP-97), were reduced similar to AD individuals compared to controls with low pathology and normal cognition [93].