Furthermore, lower expression of susceptibility genes for AD related to microglial function, such as low affinity immunoglobulin gamma Fc region receptor II-b (Fcgr2b), cathepsin H (Ctsh), hematopoietic cell-specific Lyn substrate 1 (Hcls1) or integrin subunit beta 2 (Itgb2), have been found in resilient AD-BDX mice, identified by comparing animals with intact and impaired cognition with similar amounts of Aβ pathology [180]. Here, HCLS1 is linked to Alzheimer disease.