SNAP25 and Alzheimer disease: In addition, using targeted proteomics in a larger community sample including AD and resilient samples, higher levels of STX1A, synaptotagmin 12 (SYT12), SNAP25 and syntaxin binding protein 1 (STXBP1) were associated with better cognitive performance, while STXBP4, STX7 and SYN2 correlated with a worse cognition [92].