Large-scale GWAS for AD have identified several risk loci and pathways related to lipid metabolism, such as ApoE, ATP-binding cassette transporter 1 (ABCA1) or ABCA7. As lipids provide scaffolds for neurotransmission and atrophy in AD involves the loss of structural lipids, they are likely to play a role in resilient individuals, in which often atrophy is absent and neuronal health preserved. The gene discussed is APOE; the disease is Alzheimer disease.