Increased levels of markers related to glial cells such as TREM2 and tyrosine kinase binding protein (TYROBP) have been found in the temporal cortex [238], and complement C5b-9 and HLA-DR in the entorhinal cortex and frontal gyrus superior [239] and HLA-DR, DP and DQ sub-regions in the hippocampus [240] in AD patients versus resilient donors with a high Aβ load and healthy controls. The gene discussed is TREM2; the disease is Alzheimer disease.