PICALM and Alzheimer disease: Furthermore, the absence of other well-known SNPs related to AD like clusterin (CLU), phosphatidylinositol binding clathrin assembly protein (PICALM), manganese superoxide dismutase (MnSOD), ATP binding cassette subfamily A member 7 (ABCA7) or microtubule-associated protein tau (MAPT) have been linked to better memory function in individuals that were 90 + years old [270, 271] or in resilient donors [272].