Finally, we also found that ELK1 was high expressed in APL (acute promyelocytic leukemia) compared to Acute monoblastic leukemia (Fig. 6E) derived from the public dataset (GDS1064) [87] and our findings demonstrated that overexpression of ELK1 negatively regulated erythrocyte differentiation while promoted neutrophil lineage differentiation at early stage (Fig. 6F). Here, ELK1 is linked to acute monocytic leukemia.