L-ELK1 upregulates HIFs-related genes such BNIP3 [61], VEGFA [62], EPAS1 [63], TSP1 [64], EGLN1, EGLN3 [70], ADM [71], BNIP3 [72], PLOD2 [73], STC2 [75], AQP3 [56], and PDK1 [58], and the hypoxia-related genes ANGPTL4 [57], TGFBR2 [59], LDHA [60], EOR1A [93], and CCNB1 [68], which are involved in tumor progression. Here, AQP3 is linked to neoplasm.