PRNP and carcinoma: As observed with NR3C1, TSC22D3 transcripts are reduced in adenoma versus normal tissue but further induced at the adenoma-to-carcinoma progression (Fig. 3B, C); they strongly correlate with PRNP levels, including in the large GSE39582 dataset (Fig. 3D–F) and are enriched in CMS4 CRC (Fig. 3G).