PRNP and colorectal carcinoma: This study uncovers a new gene regulatory network involving PrPC, the Wnt and Glucocorticoid signaling pathways that pertains to CRC progression and dismal outcome (Fig. 8) We have recently documented that PrPC is overexpressed in the mesenchymal, poor-prognosis subtype of CRC, and have shed some mechanistic insight into how it contributes to the mesenchymal phenotype of CRC cells [9, 32].