Accordingly and in line with our previous findings [9, 10] and those illustrated in Fig. 2G and 3G, PRNP, BACE1, DKK3, PDGFC, NR3C1 and TSC22D3 levels were all enriched in the CMS4 subgroups of tumors from the IDEA France cohort (Fig. S6A-F), uniquely composed of stage III CRC cases [24]. Here, PDGFC is linked to colorectal carcinoma.