PRNP and colonic neoplasm: Interestingly, Nr3c1 transcripts followed the same pattern of expression as Prnp (Fig. 6F), further reinforcing the link between PrPC and glucocorticoid signaling found in the context of colon cancer (see above), and the two Wnt target genes Axin2 and Ccnd1 were higher in undifferentiated as compared to differentiated tumors (Additional file 1: Fig. S5C, D).