As shown in Fig. 1D, we found that the PRNP promoter is occupied by β-catenin and harbors the active H3K4me3 mark (H3 histone tri-methylated on Lysine 4) in SW480 and DLD1 colon cancer cells in the GSE156083 dataset [27]. This evidence concerns the gene PRNP and malignant colon neoplasm.