According to our previous findings and the above data, PrPC sustains positive feedback loops with multiple effectors in colon cancer cells: TGFβ1 [9], but also the integrin linked kinase (ILK) [32], the amyloid precursor protein (APP)-derived Aβ [10], or the GR (cf above). This evidence concerns the gene PRNP and malignant colon neoplasm.