At histological examination, VilCreERT2Apcfl/+-PRNP+/− mice exhibited a small number of adenomas or in situ adenocarcinomas (Fig. 5A–C), while VilCreERT2Apcfl/+-PRNP+/+ mice were found to harbor numerous high-grade adenomas, in situ and even infiltrating adenocarcinomas, (Fig. 5A and D–E) suggesting that the overexpression of PrPC promotes colon cancer aggressiveness. Here, PRNP is linked to adenoma.