The key findings of our study are that the BLNs (1) have good biological properties, and can easily be engulfed by cancer cells and TAMs, (2) remodel both the immunogenicity of cancer cells and phenotype of TAMs, which are the key mechanisms by which BLNs boost the anti-cancer immune response and reverse the resistant of MPE to α-PD-1, (3) have a synergistic anti-cancer effect with α-PD-1, leading to a completely eradication of cancer cells in the MPE mouse model and immunological memory effects were induced. The gene discussed is RPL17; the disease is cancer.