CEACAM5 and neoplasm: In the multivariate analysis, which was adjusted for other prognostic factors such as CEA, tumor location, T4, differentiation, dMMR, and vascular invasion, the depth of PNI was identified as an independent prognostic factor for OS (HR, 3.181; 95% CI, 2.059–4.914; P < 0.001) and DFS (HR, 2.817; 95% CI, 1.744–4.549; P < 0.001).