Patients with IBD on anti-TNF-α therapy showed an increased risk of abortion (OR, 1.33; 95% CI, 1.02–1.74; P = 0.04) and a decreased rate of live birth (OR, 0.83; 95% CI, 0.74–0.94; P = 0.002) compared with controls (Fig. 2). The gene discussed is TNF; the disease is inflammatory bowel disease.