ESR1 and breast cancer: Given the sensitivity of ERα-positive BC cell lines to various kinase inhibitors (Fig. 1) and the fact that we previously discovered that Tel inhibits the IGF1-R and AKT kinases in BC cells by reducing their intracellular levels and phosphorylation status27, we proceeded to conduct Affymetrix analysis on Tel-treated ERα-positive BC cell lines to explore if additional kinases might be influenced by this drug and potentially involved in the regulation of receptor stability.