Our findings revealed that the inhibition of anaplastic lymphoma kinase (ALK) and maternal embryonic leucine zipper kinase (MELK) selectively induces ERα degradation and prevents the proliferation of cell lines representing the LumB ERα-positive/PR-negative/HER2-positive and LumA ERα-positive/PR-positive/HER2-negative molecular phenotypes of BC, respectively. This evidence concerns the gene TMEM43 and breast cancer.