Intriguingly, we found that 12 (PLK1, CDC7, AURKB, CDK1, PBK, CHK1, MELK, BUB1B, PLK4, VRK1, TTK, MASTL) out of these 17 commonly reduced kinases (Fig. 2b and Supplementary Table S3) are part of a kinase signature that distinguishes LumA BC from basal BC30. The gene discussed is MELK; the disease is breast cancer.