Given the sensitivity of ERα-positive BC cell lines to various kinase inhibitors (Fig. 1) and the fact that we previously discovered that Tel inhibits the IGF1-R and AKT kinases in BC cells by reducing their intracellular levels and phosphorylation status27, we proceeded to conduct Affymetrix analysis on Tel-treated ERα-positive BC cell lines to explore if additional kinases might be influenced by this drug and potentially involved in the regulation of receptor stability. Here, AKT1 is linked to breast cancer.