BRCA1 and gastric cancer: In the TCGA WES gastric cancer cohort, three BRCA2 deficient, four PALB2 deficient, two BRCA1 deficient and three BRCA1 promoter methylated cases all had an HRD score ≥42 (Fig. 1a, p < 1 × 10-5, Fisher exact test), which is the threshold for HR deficiency previously defined for ovarian cancer10.