In human pulmonary arterial endothelial cells (HPAEC), the efficient shRNA-mediated inhibition of FOXF1 decreased LEF1 mRNA (Fig. 4F) but increased growth of spheroids formed by human H-441 lung adenocarcinoma cells and FOXF1-deficient HPAECs (Fig. 4E). The gene discussed is LEF1; the disease is lung adenocarcinoma.