FOXF1 deficiency decreases Wnt/β-catenin signaling in TECs through direct transcriptional activation of Fzd4. Nanoparticle delivery of Fzd4 cDNA to endothelial cells rescued Wnt/β-catenin signaling in TECs, normalized tumor vessels and inhibited the progression of lung cancer. This evidence concerns the gene FZD4 and neoplasm.