Decreased tumor sizes in EEV-Fzd4-treated mice were associated with increased number of TECs expressing Fzd4 mRNA (Fig. 7E) as demonstrated by RNAscope with probes specific to Fzd4, Foxf1, and Aplnr, the latter of which is a specific marker of general capillary cells in the lung (Gillich et al, 2020). The gene discussed is FZD4; the disease is neoplasm.