Cox regression analysis revealed that TUBA1B expression had a significant impact on OS in several cancer types, including ACC (p = 0.025, HR = 2.43), BLCA (p = 0.034, HR = 1.38), BRCA (p = 0.042, HR = 1.40), KICH (p = 0.035, HR = 9.32), LGG (p < 0.001, HR = 1.91), LIHC (p = 0.011, HR = 1.57), LUAD (p < 0.001, HR = 1.73), MESO (p < 0.001, HR = 2.69), SARC (p = 0.005, HR = 1.81), SKCM (p = 0.035, HR = 1.34). The gene discussed is TUBA1B; the disease is cancer.