Elevated COLEC12, which initiates inflammation in tissues by activating the alternative complement pathway14, associated with cardioresp (OR 1.09, Fig. 1c), fatigue (OR 1.19, Fig. 1d) and anxiety/depression (OR 1.11, Fig. 1e), but not with GI (Fig. 1f) and only weakly with cognitive (OR 1.02, Fig. 1g). The gene discussed is COLEC12; the disease is major depressive disorder.