Proteins associated with the anxiety/depression (IL-1R2 P = 0.11 and MATN2 P = 0.61, Extended Data Fig. 8a) and cognitive groups (CTSO P = 0.64 and NFASC P = 0.41, Extended Data Fig. 8b) were not different between men and women in either age group, consistent with the absent/weak association between sex and these outcomes identified by PLR (Fig. 1e,g). Here, IL1R2 is linked to major depressive disorder.