Elevated IL-1R2, an IL-1 receptor expressed by monocytes and macrophages modulating inflammation11 and MATN2, an extracellular matrix protein that modulates tissue inflammation through recruitment of innate immune cells12, were associated with cardioresp (IL-1R2 OR 1.14, Fig. 1c,h), fatigue (IL-1R2 OR 1.45, Fig. 1d,h), anxiety/depression (IL-1R2 OR 1.34. This evidence concerns the gene IL1R2 and major depressive disorder.