These studies confirm that CYPA binding is required for inhibition of RAF–MEK–ERK signalling and proliferation by RMC-7977 in NCI-H441 (KRASG12V, NSCLC) and AsPC-1 (KRASG12D, PDAC) cells (Extended Data Fig. 4d–g). The gene discussed is PPIA; the disease is non-small cell lung carcinoma.