We further investigated whether exogenous CYPA expression could restore RMC-7977 sensitivity in NCI-H358 (KRASG12C, NSCLC) cells lacking PPIA. We investigated two clones expressing either low or high CYPA levels through a doxycycline-inducible promoter (Extended Data Fig. 5a). The gene discussed is PPIA; the disease is non-small cell lung carcinoma.