MST1 was related to age (P = 0.002) and tumor size (P = 0.007), YAP expression was related to gender, smoking, and grade (P = 0.033, 0.033, 0.006, respectively), SMAD3 was related to family history and grade (P = 0.004, ˂ 0.001), LATS2 was related to age (P = 0.024). The gene discussed is SMAD3; the disease is neoplasm.