These included MMP1 (involved in proliferation and differentiation) (p = 0.006), SERPINE1 (involved in tumor migration and tissue remodeling) (p = 0.005), COL5A2 (involved in cellular proliferation and invasion) (p = 0.007), and FAP (involved in familial adenomatous polyposis) (p = 0.007) that were significantly associated with poor disease-specific survival (Fig. 2e). This evidence concerns the gene MMP1 and Familial adenomatous polyposis.