Tumor cells displayed increased accessibility of 52 peaks in the 11p15 region, 8 of which linked with the expression of IGF2 oncogene, and 32 peaks in the DLK1/MEG3 locus at 14q32, including peaks linked with the expression of several genes belonging to the bad prognosis “14q32 signature” (DLK1, MEG3, RTL1, MEG8 and MEG9)17. This evidence concerns the gene RTL1 and neoplasm.