We also found that several hyper-reactive lysines were directly involved in the formation of protein complex, such as K27 in S1PR3–Gi–scFv16 complex32, K362 in DSG2-Had3K complex33, K748 in ABCB1–UIC2 complex34 and K600 in Met-InlB complex35, displaying important roles in lipid regulation, virus infection, drug transportation, and cell migration, respectively. Here, S1PR3 is linked to viral infectious disease.