In addition to small molecule compounds that modulate the expression of TFAM, the oncogene c-Myc promotes nuclear transcription of TFAM, facilitating sarcoma growth, while Fructose-1,6-Bisphosphatase 2 (FBP2) overexpression inhibits c-Myc-mediated transcriptional regulation of TFAM [105]. This evidence concerns the gene MYC and sarcoma.