Changes in this transcriptional machinery may significantly disrupt mitochondrial function, energy metabolism, and muscle homeostasis.Research on animal models of cancer-induced cachexia has revealed a decrease in mitochondrial mass and levels of mitochondrial DNA in skeletal muscle [124, 128, 132], along with a significant decrease in the expression of genes regulating mitochondrial biogenesis, such as PGC-1α and TFAM [133, 134]. The gene discussed is TFAM; the disease is cancer.