The classic EMT phenotypes, including the downregulation of E-cadherin and the upregulation of N-cadherin, were observed in both TGM3-knockdown cSCC cells and the TGM3-knockdown subcutaneous xenograft tumor model (Fig. 4D, lower right panel; Figs. 4F; S2B, C, right panel, S2D, right panel, and S3D). This evidence concerns the gene CDH2 and neoplasm.