We also found that pERK suppression via RMC-7977 in colon tissues from the KPF/FC cohort was rapidly restored to baseline at the 10 and 25 mg kg−1 dose levels, whereas pathway suppression was more prolonged in tumours at these doses (Fig. 3c and Extended Data Fig. 3e, f). This evidence concerns the gene EIF2AK3 and neoplasm.