TSPYL2 and cancer: Knowledge of the various mechanisms to stabilize TSPYL2 will provide understanding on how TSPYL2 helps the cell to cope with stresses such as DNA damage.[31] Independent studies have established that ectopic expression or induction of TSPYL2 by various stresses induces growth arrest or apoptosis in cancer stem cells, cancer cell lines, human embryonic lung fibroblasts, and human mesenchymal stem cells.[7, 26, 32] It is possible that stabilized TSPYL2 and the negative effects on cell proliferation and differentiation may be the caveats in SIDDT.