In order to elucidate the potential mechanisms of NCAPH regulating glioma cells, 2086 DEGs relevant to NCAPH were obtained for enrichment analysis and enriched in PI3K/AKT signaling pathway (Fig. 4c), which not only involves in the regulation of cell cycle, DNA damage, apoptosis, and cell proliferation but also regulates the invasion and migration of tumor cells [19, 25–28]. Here, AKT1 is linked to central nervous system cancer.