Among the identified mutations related to intellectual disability, we found, for example, the CIC c.6746 A > C; p.(Lys2249Thr) an autosomal dominant mutation in the CIC gene associated with intellectual disability type 45 [51] and the recurrent deletion/duplication of the 15q13.3 region associated with phenotypes with different degrees of intellectual disability [52]. Here, CIC is linked to Intellectual disability.