MTOR and type 2 diabetes mellitus: The link between the TOR pathway and tRNA modifications like t6A is conserved among the eukaryotes: A loss of modifications at the ASL decreases rapamycin resistance in S. cerevisiae (11, 19), KEOPS complex mutants in Drosophila resemble TOR pathway-deficient mutants (90), disturbance of tRNA-modifying enzymes reduces the TOR-driven cell growth in Arabidopsis thaliana (91), and a hypomodified adenosine residue at position 37 of tRNAs is considered a risk factor for type 2 diabetes in humans as a consequence of mTOR overactivation (92, 93).