However, the absolute effect of tBCAAs/glycine ratio (P-gain >10) on CHD was significantly larger compared with the effect of glycine, estimated without CPS1 variant, in the CARDIoGRAMplusC4D and in meta-analyzed data set of the 3 cohorts (IVW, weighted median, and MR-PRESSO methods). This evidence concerns the gene CPS1 and coronary artery disorder.