Consistent with these published findings, our data also showed that postprandial FGF19 concentrations (180 minutes after mixed meal) decreased in people with obesity (average BMI = 41), patients with obesity and T2D (average BMI = 39), and patients with obesity and MASLD (no T2D) (average BMI = 40) compared with lean people (average BMI = 23.5) (Figure 1A). The gene discussed is FGF19; the disease is obesity due to melanocortin 4 receptor deficiency.