PCDHGB7 and cancer: To further improve the efficiency of cfDNA methylation detection in PEs, we identified a UCOM marker, TAGMe, a significantly differentially methylated region (DMR) located in the intergenic region in chromosome 3p26.1, that outperformed PCDHGB7 in several cancer types, including lung, colorectal, kidney, prostate, and bile duct cancers (Figure 2D and Supplemental Tables 2 and 3).