We further identified that endothelial Kir2.1 channels are also robustly impaired in mesenteric visceral adipose arteries of obese mice and humans yet retain functionality in subcutaneous adipose artery endothelium, thereby indicating differential effects of obesity on endothelial Kir2.1 when located in VAT versus SAT (5). The gene discussed is KCNJ2; the disease is obesity due to melanocortin 4 receptor deficiency.