Here we used a well-established mouse model of diet-induced obesity that we recently showed recapitulates the obese human condition in regard to VAT versus SAT endothelial function to determine the role of CD36 in mediating obesity-induced endothelial and Kir2.1 dysfunction in VAT arteries. This evidence concerns the gene KCNJ2 and obesity due to melanocortin 4 receptor deficiency.