Although Naito et al. identified HLA-DRB1 locus (rs504594) associated with HLA-DRB1*04 in East Asians (Naito et al., 2021), it is important to note that this finding was not replicated in two other PD-related GWAS in Asia (Foo et al., 2020; Pan et al., 2023), which did not identify any HLA alleles. This evidence concerns the gene HLA-DRB1 and Parkinson disease.