HLA gene, especially HLA-DRB1, widely regarded relevant to the susceptibility of PD in Caucasian population, although specifics loci differ (Hamza et al., 2010; Guo et al., 2011; Nalls et al., 2011; Ahmed et al., 2012; Wissemann et al., 2013; Nalls et al., 2014; Chuang et al., 2017; Hollenbach et al., 2019; Chang et al., 2020;Naito et al., 2021; Yu et al., 2021; Le Guen et al., 2023). This evidence concerns the gene HLA-DRB1 and Parkinson disease.