Among them, ‘Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer’s disease - is this type 3 diabetes?’ (Steen et al., 2005), published in Journal of Alzheimer’s Disease in 2005, has been most cited (1,266 Citations), followed by ‘Promoting Axon Regeneration in the Adult CNS by Modulation of the PTEN/mTOR Pathway’ (Park et al., 2008), published in Science in 2008 (1,139 Citations), and ‘PTEN deletion enhances the regenerative ability of adult corticospinal neurons’ (Liu K et al., 2010), published in Nature Neuroscience in 2010 (668 Citations). The gene discussed is MTOR; the disease is early-onset autosomal dominant Alzheimer disease.