The frequency figures are labelled in Figure 8, mainly covering the signaling molecules, such as akt (21 times), PI3K (13 times), and mTOR (13 times), the cellular mechanisms, such as apoptosis (18 times), axon regeneration (18 times) and inflammation (7 times), and diseases including spinal cord injury (20 times), Parkinson’s disease (7 times) and autism (7 times), which may be hotspots and targets of further research trends on the study of PTEN in the nervous system. This evidence concerns the gene MTOR and autism.