Here, we present the case of a patient with <i>BRCA1</i>-positive breast cancer in remission and a history of ovarian cancer with mediastinal lymphadenopathy and pulmonary nodules, with avid fluorodeoxyglucose uptake on positron emission tomography (PET) scan and elevated CA 15-3 and CA 27-29. The gene discussed is BRCA1; the disease is ovarian carcinoma.