Furthermore, the results indicated an increase in the expression of DEGs related to the reactive oxygen species pathway (NDUFB4, PDLIM1, GPX4, and JUNB), and a decrease in the expression of SOD, which has an antioxidant function, in the presence of idiopathic pulmonary hypertension (Figure 3D). The gene discussed is JUNB; the disease is pulmonary arterial hypertension.