EBF1 and B-cell chronic lymphocytic leukemia: Furthermore, the early compartmental switch (A to I) of the EBF1 factor in B cells of patients with chronic lymphocytic leukemia results in the loss of chromatin interactions, and therefore, the downregulation of EBF1 has become a diagnostic marker for chronic lymphocytic leukemia (Vilarrasa-Blasi et al., 2021).