BACE1 and psychiatric disorder: Lanabecestat (Fig. 17) was developed as an anti-alzheimer drug that has the ability to pass the BBB and improve the clinical features, along with preventing the progression of the disease through inhibition of BACE1.167 The data obtained from some studies reflected adverse effects that include psychiatric disorders, weight loss, and change in hair color, while there was no considerable improvement in primary or secondary efficacy measures.167,168